Final fight works on 4.41.2 and up.
REX 4.46.1 and my slim with broken bd didn't get along. From trophy errors down to broken movie playback. I switched to 4.46.1 lite and it seems more stable then the 4.46 drex and rex versions so far. I do know SEN Enabler and 4.46 doesnt get along very well by my experiences on these cfw's.
Iris and Multiman seem to do better with lite as well. Iris doesn't pick up the second disc for skyrim on rex or drex but lite it pops up just fine. Also random game compatibility issues are better with lite. I even got Bejeweled 2 (jap version) going fine. It was previously unplayable on cfw.