I got this game working w/ 4.13.00 multiMAN and 4.21.1 REX. As a matter of fact, I just finished going through all 170+ retail games and every one works with the latest official updates, no patching necessary. If you want to know specifics on how I have certain game settings, let me know which ones and I'll share with you.
I plan on making a text document to upload with all of my info, (game configurations internal/external etc.) but that will take some time. Also, I know it was a big pain in the rear, but when I upgraded to REX 4.21.1 I reformatted my int. hdd so I could start from scratch.